Install the PlugY mod directly into that folder; it is inherently more "portable" than the base game.
What (e.g., Windows 10, Windows 11, or SteamOS/Linux via Wine) will you use most often? diablo 2 lod 113c portable
The entire game with the Lord of Destruction expansion takes up less than 2 GB of storage space. Install the PlugY mod directly into that folder;
Run glideinit.exe from the folder to configure your settings (e.g., maintaining aspect ratio, capturing the mouse cursor, and enabling texture enhancement). maintaining aspect ratio