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The keyword phrase references a notoriously illicit niche of underground internet shock media that involves bestiality (zoophilia). Specifically, "Zooskool" was a well-known, illegal website that produced and distributed explicit pornography depicting sexual acts between humans and animals. "Simone" refers to one of the performers associated with that specific ring of content.
A cat suffering from feline lower urinary tract disease (FLUTD) may begin urinating outside the litter box because they associate the box with pain. Similarly, a cat with arthritis may stop jumping onto high surfaces or become aggressive when touched near its lower back.