Throughout her career, Dejo has balanced roles in popular television series, reality competitions, and film. Her recent and most notable credits include: Tu nombre y el mío

Through her Instagram stories, Dejo curates the latest musical releases, both national and international, every Saturday. She engages directly with her fanbase, giving away prizes, discussing hit singles, and interviewing up-and-coming artists. In the promotional post, she wrote: "Happy to announce the start of Karen's TikTop, with the best of current music, you will learn about the new national and international releases, you will have fun with our sequences, you will be able to learn a little more about your favorite artists and we will give away many prizes."

As traditional television viewership shifted toward digital spaces, Karen Dejo adapted by turning her personal brand into highly transactional digital content.