Run Steam and RE6 with strict permissions:

The most frequent fix is ensuring both Steam and the game have the same permission levels. Completely close Steam. Locate the file in your installation folder.

Case C — Using mods or third-party overlays (e.g., ReShade, RTSS)

is a massive, over-the-top action horror game that still maintains a loyal player base on PC. However, few things are as frustrating as installing this classic only to be greeted by a gray dialog box bearing the dreaded message: "Failed to initialize Steam. Are you sure Steam is running?"